Indication
Antihypertensive
Dose
Dose are individualized depending on the patient condition. Please consult your doctor or pharmacist for the suggestion of treatment for your hypertension. Once you started your hypertension medication, take the medication regularly and accordingly.
Administration
Generally, it is advisable to be taken with meals to reduce stomach discomfort. Otherwise, refer product insert for specific instruction :
Generic Name | Administration |
Minoxidil |
With or without food |
Bosentan |
With or without food |
Ambrisentan |
With or without food |
Mechanism Of Action
Primarily are vasodilators drugs. The drug relax the smooth muscle in blood vessels, which causes the vessels to dilate. Dilation of arterial (resistance) vessels leads to a reduction in systemic vascular resistance, which leads to a fall in arterial blood pressure. Dilation of venous vessels, decreases venous blood pressure.
Side Effects
Side effects for each drugs are individualized. Most common side effects for each drugs are listed below :
Generic Name | Possible common side effects include |
Minoxidil | Sodium and water retention, weight gain, peripheral oedema (swollen of the feet or hand due to fluid retention), tachycardia (faster than normal heart rate), gastrointestinal disturbances, rashes |
Bosentan | Headache, flushing, oedema (swollen due to fluid retention), hypotension, palpitations, fatigue, pruritis |
Ambrisentan | Headache, peripheral oedema, fluid retention, palpitation, abdominal pain, constipation, flushing |
Consult your doctors or pharmacists if you are facing any side effects from the antihypertensive drugs that you are taking.
Storage
Advisable to be keep in the original envelopes with instructions on how to take clearly stated on labels. Keep at room temperature otherwise, refer product insert for specific temperature storage.
For further information, refer MyHealth web site ‘Cara Penyimpanan Ubat Yang Betul’.
References
- Mechanism of Action of Angiotensin Converting Enzyme http://www.cvpharmacology.com/Acilliary/search
- http://pharmacologycorner.com/mechanism-of-action-video
- British National Formulary (BNF) 61 March 2011
- MIMS 128th Edition 2012
- Mechanism of Action of Vasodilator Drugs. http://www.cvpharmacology.com/Acilliary/search
- ‘Cara Penyimpanan Ubat Yang Betul’. (http://www.myhealth.gov.my/v2/index.php/my/ubat-a-anda/umum/cara-penyimpanan-ubat-yang-betul)
Last Reviewed | : | 2 March 2016 |
Writer | : | Pn. Azura Binti Musa |
Translator | : | Pn. Azura Binti Musa |
Accreditor | : | Dr. Siti Norlina Binti Md. Said |