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Utama > Hypertension > Treatment With Medicine : Others

Treatment With Medicine : Others

Indication

Antihypertensive

Dose

Dose are individualized depending on the patient condition. Please consult your doctor or pharmacist for the suggestion of treatment for your hypertension. Once you started your hypertension medication, take the medication regularly and accordingly.

Administration

Generally, it is advisable to be taken with meals to reduce stomach discomfort. Otherwise, refer product insert for specific instruction :

Generic Name Administration

Minoxidil

1

With or without food

Bosentan

2

With or without food

Ambrisentan

3

With or without food

Mechanism Of Action

Primarily are vasodilators drugs. The drug relax the smooth muscle in blood vessels, which causes the vessels to dilate. Dilation of arterial (resistance) vessels leads to a reduction in systemic vascular resistance, which leads to a fall in arterial blood pressure. Dilation of venous vessels, decreases venous blood pressure.

Side Effects

Side effects for each drugs are individualized. Most common side effects for each drugs are listed below :

Generic Name Possible common side effects include
Minoxidil Sodium and water retention, weight gain, peripheral oedema (swollen of the feet or hand due to fluid retention), tachycardia (faster than normal heart rate), gastrointestinal disturbances, rashes
Bosentan Headache, flushing, oedema (swollen due to fluid retention), hypotension, palpitations, fatigue, pruritis
Ambrisentan Headache, peripheral oedema, fluid retention, palpitation, abdominal pain, constipation, flushing

Consult your doctors or pharmacists if you are facing any side effects from the antihypertensive drugs that you are taking.

Storage

Advisable to be keep in the original envelopes with instructions on how to take clearly stated on labels. Keep at room temperature otherwise, refer product insert for specific temperature storage.

For further information, refer MyHealth web site ‘Cara Penyimpanan Ubat Yang Betul’.

References

  1. Mechanism of Action of Angiotensin Converting Enzyme http://www.cvpharmacology.com/Acilliary/search
  2. http://pharmacologycorner.com/mechanism-of-action-video
  3. British National Formulary (BNF) 61 March 2011
  4. MIMS 128th Edition 2012
  5. Mechanism of Action of Vasodilator Drugs. http://www.cvpharmacology.com/Acilliary/search
  6. ‘Cara Penyimpanan Ubat Yang Betul’. (http://www.myhealth.gov.my/v2/index.php/my/ubat-a-anda/umum/cara-penyimpanan-ubat-yang-betul)
Last Reviewed : 2 March 2016
Writer : Pn. Azura Binti Musa
Translator : Pn. Azura Binti Musa
Accreditor : Dr. Siti Norlina Binti Md. Said

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