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Focal Segmental Glomerulosclerosis (FSGS)


Each person has 2 kidneys situated in the lower back. Each kidney is made up of ~ 1 million tiny filtering units called the “glomeruli”. The glomeruli filter or cleanse our blood continuously to produce urine to remove waste products, salts and excess water from our body. Diseases that affect the glomeruli are called glomerulopathy or glomerulonephritis. When glomeruli become damaged, protein and blood may leak into the urine resulting in proteinuria or haematuria. This may also result in body swelling, high blood pressure and even kidney failure.

Membranous Nephropathy (Glomerulopathy)

 FSGS is a disease that causes urinary loss of protein and eventual scarring (sclerosis) of the glomeruli. Focal is used because only some of the glomeruli or filters are affected and segmental means only part of a single glomerulus or filter is scarred.


Focal segmental glomerulosclerosis is a common glomerulopathy affecting people of all ages, especially those < 45 years old.

From the 2nd Report of the Malaysian Registry of Renal Biopsy, FSGS accounts for 30% of all primary glomerulonephritis. The mean age at biopsy was 32.5 ± 13.5 years.

Demographic characteristics for FSGS, 2005-2008, Malaysia


FSGS may be “primary” which means the disease happens on its own, without any obvious causes; or “secondary”, where the FSGS is caused or associated with another medical condition.

Some of the secondary causes/associations of FSGS are:

  • Kidney defects from birth
  • Reflux nephropathy – where urine flows back up into the kidneys
  • Obesity
  • Viruses eg HIV
  • Other kidney diseases that lead to scarring


Patients with FSGS may present with the following:

  • Asymptomatic urinary abnormalities – detection of protein and sometimes blood in the urine without patients experiencing any clinical symptoms
  • Foamy urine or bubbles in the urine –some people may notice this when there is a large amount of protein leakage in their urine
  • Oedema or Nephrotic syndrome – body swelling especially around the eyes, feet and hands. This is due to the leakage of a large amount of protein in the urine.
  • High blood pressure
  • Low blood protein level
  • High blood cholesterol level
  • Impaired kidney function

From the 2nd Report of the Malaysian Registry of Renal Biopsy, the majority (65%) of patients with FSGS presented with nephrotic syndrome. 21% presented with asymptomatic urinary abnormalities. High blood pressure was found in 18% of cases and 41% presented with impaired kidney function (eGFR< 60mls/min).


Your doctor will usually order a series of tests and these includes:

  • Urine tests : to detect protein and blood in the urine and to quantify the amount of protein leakage in the urine
  • Blood tests: to determine the levels of protein, albumin, cholesterol in the blood, to determine the level of kidney functions and to look for possible secondary causes.
  • Kidney Ultrasound : to assess the size and structure of the kidneys (especially with impaired kidney function and in preparation for kidney biopsy)
  • Kidney biopsy: to get a small piece of kidney tissue for examination under the microscope. This test is needed to confirm the diagnosis of FSGS, distinguish the different types of FSGS, guide treatment and provide information about prognosis.


Normal glomerulus               Glomerulus with FSGS


Various medications may be given by your doctors and these includes:

  • Diuretics eg frusemide, spironolactone, hydrochlorthiazide etc: this is to reduce or control the body swelling
  • ACE inhibitor or ARB eg perindopril, enalapril, ramipril, losartan, irbesartan, valsartan, telmisartan etc: this blocks the renin-angiotensin hormone system and helps to control blood pressure and the amount of protein leakage in the urine
  • Other antihypertensives eg amlodipine, nifedipine, metoprolol, prazosin etc: this helps to control/lower the blood pressure that may be associated with FSGS
  • Statins eg lovastatin, simvastatin, atorvastatin, pravastatin etc: this helps to lower the blood cholesterol level
  • Anticoagulants eg warfarin, heparin may be needed to prevent blood clots from forming
  • Immunosuppressants eg prednisolone, cyclosporine, tacrolimus, cyclophosphamide, azathioprine, mycophenolate mofetil (MMF) : these are used in the more severe cases to alter your immune system and try to cure the disease

Patients are also advised to stop smoking, take low salt diet and have a healthy lifestyle.

Prognosis /Outcome

The natural history of FSGS varies a great deal. Treatment may cure the disease or slow down the disease progression in some patients. Some patients who responded to treatment initially may relapse (disease may come back again). Some patients may eventually develop kidney failure although the time varies widely from 2-20 years. The severity of proteinuria, kidney biopsy changes, and response to treatment may help to predict the outcome.

Patients with FSGS who progress to end-stage kidney failure may be transplanted although the FSGS may return in the transplanted kidney in 20-50% of cases.

Last Reviewed : 27 May 2016
Writer : Dr. Clare Tan Hui Hong
Accreditor : Dr. Goh Bak Leong

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