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Utama > Hypertension > Central Acting Inhibitor

Central Acting Inhibitor

Indication

Antihypertensive

Dose

Dose are individualized depending on the patient condition. Please consult your doctor or pharmacist for the suggestion of treatment for your hypertension. Once you started your hypertension medication, take the medication regularly and accordingly.

Administration

Generally, it is advisable to be taken with meals to reduce stomach discomfort. Otherwise, refer product insert for specific instruction:

Generic Name Administration

Methyldopa

1

With or without food

Mechanism Of Action

Centrally acting sympatholytics block sympathetic activity by binding to and activating alpha2 (?2)-adrenoceptors. This reduces sympathetic outflow to the heart thereby decreasing cardiac output by decreasing heart rate and contractility. Reduced sympathetic output to the vasculature decreases sympathetic vascular tone, which causes vasodilation and reduced systemic vascular resistance, which decreases arterial pressure.

This class of antihypertensive is commonly use for the management of hypertension in pregnancy.

Side Effects

Side effects for each drugs are individualized. Most common side effects for the drug is listed below:

Generic Name Possible common side effects include
Methyldopa Sedation, headache, weakness, dizziness, orthostatic hypotension, gastrointestinal discomfort, impotence

Consult your doctors or pharmacists if you are facing any side effects from the antihypertensive drugs that you are taking.

Storage

Advisable to be keep in the original envelopes with instructions on how to take clearly stated on labels. Keep at room temperature otherwise, refer product insert for specific temperature storage.

For further information, refer MyHealth web site ‘Cara Penyimpanan Ubat Yang Betul’.

References

  1. Mechanism of Action of Angiotensin Converting Enzyme http://www.cvpharmacology.com/Acilliary/search
  2. http://pharmacologycorner.com/mechanism-of-action-video
  3. British National Formulary (BNF) 61 March 2011
  4. MIMS 128th Edition 2012
  5. Mechanism of Action of Centrally Acting Symphatolytics http://www.cvpharmacology.com/Acilliary/search
  6. ‘Cara Penyimpanan Ubat Yang Betul’ (http://www.myhealth.gov.my/v2/index.php/my/ubat-a-anda/umum/cara penyimpanan-ubat-yang-betul)
Last Reviewed : 2 March 2016
Writer : Pn. Azura Binti Musa
Translator : Pn. Azura Binti Musa
Accreditor : Dr. Siti Norlina Binti Md. Said

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