PENDIDIKAN PESAKIT Kementerian Kesihatan Malaysia
Indication
Antihypertensive
Dose
Dose are individualized depending on the patient condition. Please consult your doctor or pharmacist for the suggestion of treatment for your hypertension. Once you started your hypertension medication, take the medication regularly and accordingly.
Administration
Generally, it is advisable to be taken with meals to reduce stomach discomfort. Otherwise, refer product insert for specific instruction:
| Generic Name | Administration |
| Prazosin
|
With or without food. Starting dose is best taken with dinner, at least 2-3 hours before retiring. Maintenance doses may be taken with or without meals. |
Mechanism of Action
Alpha-blockers binds to alpha-adrenoceptors located on the vascular smooth muscle both on arteries and veins, therefore dilate both arteries and veins and thus reduce the blood pressure.
Side Effects
Side effects for each drugs are individualized. Most common side effects for the drug are listed below:
| Generic Name | Possible Common Side Effects Include |
| Prazosin | Postural hypotension (a drop in blood pressure due to a change in body position /posture), headache, gastrointestinal upset, oedema, tinnitus (hearing ringing, buzzing, or other sounds without an external cause in the one or both ears or in the head), fluid retention |
Consult your doctors or pharmacists if you are facing any side effects from the antihypertensive drugs that you are taking.
Storage
Advisable to be keep in the original envelopes with instructions on how to take clearly stated on labels. Keep at room temperature otherwise, refer product insert for specific temperature storage.
References
- Mechanism of Action of Angiotensin Converting Enzyme http://www.cvpharmacology.com/Acilliary/search
- http://pharmacologycorner.com/mechanism-of-action-video
- British National Formulary (BNF) 61 March 2011
- MIMS 128th Edition 2012
- Mechanism of Action of Alpha Blocker
- http://www.cvpharmacology.com/Acilliary/search
- ‘Cara Penyimpanan Ubat Yang Betul’ (http://www.myhealth.gov.my/v2/index.php/my/ubat-a-anda/umum/cara-penyimpanan-ubat-yang-betul)
| Last Reviewed | : | 2 March 2016 |
| Writer | : | Azura Binti Musa |
| Translator | : | Azura Binti Musa |
| Accreditor | : | Dr. Siti Norlina Binti Md. Said |
